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Tylenol Interactions. There are 129 drugs known to interact with Tylenol (acetaminophen), along with 3 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 8 are major, 85 are moderate, and 36 are minor. Compare to the active ingredients in Extra Strength Tylenol PM; Acetaminophen 500 mg/pain reliever; Diphenhydramine HCl 25 mg/nighttime sleep aid. 100 Unisom sleep pills have a different active ingredient than Benadryl. Tylenol PM has the Benadryl active ingredient. Unisom and Benadryl affect Vicks Sleep Aid Liquid, Diphenhydramine HCI, Over-the-Counter Medicine, Warming TYLENOL Acetaminophen, PM, Extra Strength, Caplets. Family Pack. TYLENOL nocuf syrup active ingredient Tylenol PM contains the same ingredient as Benadryl (only it also has Tylenol). So, in essence, you’d be taking 3 Benadryls a Tylenol. Your Ingredients. Active Ingredients (in Each Caplet): Acetaminophen (500 mg), Diphenhydramine HCl (25 mg). Inactive Ingredients: Carnauba Wax Only TYLENOL Cold Multi-Symptom Liquid (Nighttime) contains doxylamine succinate, an antihistamine, which may cause marked drowsiness. Ask a doctor or

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