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by JD Torres-Peña 2024 Cited by 21In fact, the rate of acute liver failure in patients that are taking statins is very close to the general population (49). However, cases have been described of In one study performed on 30 cirrhotic patients, the use of 40 mg oral simvastatin resulted in acute hemodynamic effects in the liver, with a decrease in hepatic vascular resistance (-14%) and an increase in hepatic blood flow (20%), only around 30 min after the time of administration. The hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are the most potent, best tolerated and most widely used oral cholesterol lowering agents and represent some of the most commonly prescribed medications in the United States. HMG-CoA reductase is the rate limiting step in cholesterol synthesis by the liver, and inhibition of its activity causes a significant Studies show that more cases of acute liver failure are caused by prescription and over-the-counter drugs (OTC), herbs, and dietary supplements than all other Recently, the risk of statin-induced liver injury has become a hot topic, since this class of drugs is metabolized by enzymes in the liver. Liver injury has a broad definition, but generally includes, at minimum, highly elevated liver enzymes which are directly correlated with liver function and often a precursor to various liver diseases.

amaize cream by LW Unger 2024 Cited by 9Statins reduce cardiovascular risk. However, real-life data on statin use in patients with chronic liver disease and its impact on overall Some evidence of benefit from statins in liver disease comes from basic research. Chemotherapy agents are linked to idiosyncratic drug-induced liver injury (DILI), most commonly seen with kinase inhibitors, describing higher rates in CLD patients. Anthracycline antibiotics, such as doxorubicin, has been associated to DILI. Based on reviewed literature, statins appear to be associated with a very low risk of true and serious liver injury. Unprecedented fears regarding hepatic adverse effects of statins among prescribers and patients can deny patients of the significant benefits of these agents. Statins are a class of medicines used to lower cholesterol. While some of the cholesterol in your blood comes from food, most is made by the liver. Statins work The liver is the largest gland in the body, located in the upper right part of the belly. It is the body s master detoxer of drugs and other foreign substances. It stores glycogen, which the

Another class of medications that sometimes causes liver enzymes to rise are cholesterol lowering medications, called statins. Statins include the medications simvastatin, atorvastatin, pravastatin and lovastatin. Statins rarely cause liver damage, and doctors no longer check liver enzymes for people on statins routinely.

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